Impetigo treatment steroid cream

Clinical cure, defined as ≥80% cured lesions (fully recovered lesions, visually determined by investigators), was achieved by % and % of FMX-102 1% and 4% subjects, respectively, at the end of treatment (visit 3). Clinical success, defined as the absence of lesions, or the drying or improvement of treated lesions (decrease in size of affected area, lesion number, or both), was demonstrated in % and % of FMX-102 1% and 4% subjects, respectively, following 3 days of treatment (visit 2), in % and 100% of the respective subjects at the end of treatment, and in 100% in both groups at follow-up (visit 4). Bacteriologic success rates at the end of treatment, defined as complete pathogen eradication, were 85% and 74% in the FMX-102 1% and 4% groups, respectively. The bacteriologic success rate for MRSA infections was 100% (11/11), with no recurrences. Both FMX-102 1% and 4% were considered well tolerated and safe.

Admissions for skin and soft-tissue infections have been increasing steadily in children and in the general population. Concerns have been raised recently about the increasing widespread use of topical fusidic acid and concurrent increase of fusidic acid-resistant Staphylococcus aureus. Fusidic acid resistance and methicillin resistant Staphylococcus aureus (MRSA) are both more prevalent in youngest age group (<5 year-olds) and particularly in the North island. In New Zealand, fusidic acid is recommended for treatment of minor impetigo and is the only fully-funded topical antibiotic. The evidence base for alternative treatment strategies for mild impetigo is limited. Most children with impetigo in the current Counties Manukau skin and sore throat schools programme received care with wound management with only a few requiring escalation. An upcoming randomised controlled trial comparing topical hydrogen peroxide cream, topical fusidic acid and wound management only (clean and cover) will help provide evidence about the effectiveness of alternative treatments in the New Zealand setting.

The gravest potential complication of impetigo is post-streptococcal glomerulonephritis, a severe kidney disease that occurs following a strep infection in less than 1% of cases, mainly in children. The most common cause of impetigo is Staphylococcus aureus . However, another bacteria source is group A streptococcus . These bacteria lurk everywhere. It is easier for a child with an open wound or fresh scratch to contract impetigo. Other skin-related problems, such as eczema , body lice , insect bites , fungal infections, and various other forms of dermatitis can make a person susceptible to impetigo.

According to several systematic reviews, mupirocin was as effective as several oral antibiotics (dicloxacillin [Dynapen], cephalexin [Keflex], ampicillin). Oral antibiotics are recommended for patients who do not tolerate a topical antibiotic, and should be considered for those with more extensive or systemic disease. Basic prescribing information is summarized in Table 3 . One study comparing fusidic acid and cefuroxime found no difference in effectiveness, and both mupirocin and fusidic acid were consistently more effective than oral erythromycin. 4 , 7 Although patients with more extensive impetigo and those with systemic symptoms often are treated with oral antibiotics, there were no studies comparing oral and topical antibiotics in this subset of patients. Oral antibiotics can be used, however, based on expert opinion and traditional practice. 8 Adverse effects, particularly nausea, are more common with oral antibiotics, especially erythromycin, than with topical antibiotics. 8

Impetigo treatment steroid cream

impetigo treatment steroid cream

According to several systematic reviews, mupirocin was as effective as several oral antibiotics (dicloxacillin [Dynapen], cephalexin [Keflex], ampicillin). Oral antibiotics are recommended for patients who do not tolerate a topical antibiotic, and should be considered for those with more extensive or systemic disease. Basic prescribing information is summarized in Table 3 . One study comparing fusidic acid and cefuroxime found no difference in effectiveness, and both mupirocin and fusidic acid were consistently more effective than oral erythromycin. 4 , 7 Although patients with more extensive impetigo and those with systemic symptoms often are treated with oral antibiotics, there were no studies comparing oral and topical antibiotics in this subset of patients. Oral antibiotics can be used, however, based on expert opinion and traditional practice. 8 Adverse effects, particularly nausea, are more common with oral antibiotics, especially erythromycin, than with topical antibiotics. 8

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