Receptores intracelulares esteroides

α 1 -adrenergic receptors are members of the G q protein-coupled receptor superfamily. Upon activation, a heterotrimeric G protein, G q , activates phospholipase C ( PLC ). The PLC cleaves phosphatidylinositol 4,5-bisphosphate (PIP2), which in turn causes an increase in inositol triphosphate (IP3) and diacylglycerol (DAG). The former interacts with calcium channels of endoplasmic and sarcoplasmic reticulum, thus changing the calcium content in a cell. This triggers all other effects, including a prominent slow after depolarizing current (sADP) in neurons [12]

Receptores intracelulares esteroides

receptores intracelulares esteroides

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