" 'Poochiao' got three losses and two draws and been knocked out twice," Mayweather said. "So, like I said before, once I beat him it's going to be a cakewalk and it's on to the next... We know Pacquiao made $6 million in his last fight and Floyd Mayweather made $65 million in his last fight. Three losses, two draws. Ohhh, hell no, this is America baby. We built on winning. Step your game up, f----t... That mother f----- Pacquiao, he can't speak no English. He never seen a contract he didn't like. Mother f----- signed with two companies [Top Rank and Golden Boy]. Look it up. And then this mother f------ with Nike only got 70 Gs. How stupid can a mother f----- be? Reebok gave me a million dollars for three weeks. I wore Reebok s--- for a week for a million dollars... This mother f------'s name is Emmanuel. He got a fake name, taking power pellets."
Sex hormone-binding globulin (SHBG) is thought to mainly function as a transporter and reservoir for the estradiol and testosterone sex hormones. However it has also been demonstrated that SHBG can bind to a cell surface receptor (SHBG-R). The SHBG-R has not been completely characterized. A subset of steroids are able to bind to the SHBG/SHBG-R complex resulting in an activation of adenylyl cyclase and synthesis of the cAMP second messenger.  Hence the SHBG/SHBG-R complex appears to act as a transmembrane steroid receptor that is capable of transmitting signals to the interior of cells.