Steroid alkaloid glycosides from solanum robustum

Injection of tomatine into mice caused a rapid drop in blood pressure. This is presumably the result of tomatine-induced disruption of red blood cell membranes. (Cholesterol seems to protect the erythrocytes. [38] [39] Intraperitoneal injection of tomatine results in a decrease of diuresis in rats. This effect is accompanied by increased corticosteroid and neutrophil levels and a decrease in the Na/K ratio in the serum. [17] The oral administration of tomatine in doses of 15–30 mg/kg or the intramuscular administration in the dose range of 1–10 mg/kg  induces a dose-dependent inhibition of induced edema [17] similar anti-inflammatory effects are noted when tomatine is administered subcutaneously.

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Steroid alkaloid glycosides from solanum robustum

steroid alkaloid glycosides from solanum robustum

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