Injection of tomatine into mice caused a rapid drop in blood pressure. This is presumably the result of tomatine-induced disruption of red blood cell membranes. (Cholesterol seems to protect the erythrocytes.   Intraperitoneal injection of tomatine results in a decrease of diuresis in rats. This effect is accompanied by increased corticosteroid and neutrophil levels and a decrease in the Na/K ratio in the serum.  The oral administration of tomatine in doses of 15–30 mg/kg or the intramuscular administration in the dose range of 1–10 mg/kg induces a dose-dependent inhibition of induced edema  similar anti-inflammatory effects are noted when tomatine is administered subcutaneously.