Steroid use rates

Michael A. Ball, DVM, completed an internship in medicine and surgery and an internship in anesthesia at the University of Georgia in 1994, a residency in internal medicine, and graduate work in pharmacology at Cornell University in 1997, and was on staff at Cornell before starting Early Winter Equine Medicine & Surgery located in Ithaca, . He is also an FEI veterinarian and works internationally with the United States Equestrian Team. Ball authored Understanding The Equine Eye , Understanding Basic Horse Care , and Understanding Equine First Aid , published by Eclipse Press and available at or by calling 800/582-5604.

This obsession has become so common that Dr. Pope has come up with a term for it: Adonis Complex. What fuels it, he says, are the ridiculously outsized bodies purveyed by Hollywood, magazine covers, and even action-toy manufacturers (just check out the size of . Joe these days). "One of the biggest lies being handed to American men today is that you can somehow attain by natural means the huge shoulders and pectorals of the biggest men in the magazines," says Dr. Pope. "Generations of young men are working hard in the gym and wondering what on earth they're doing wrong. They don't realize that the 'hypermale' look that's so prevalent these days is essentially unattainable without steroids."

About the National Institute on Drug Abuse (NIDA):  The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, . Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at , which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDA’s DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to drugpubs@ . Online ordering is available at . NIDA’s media guide can be found at /publications/media-guide/dear-journalist , and its easy-to-read website can be found at . You can follow NIDA on Twitter and Facebook .

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

Steroid use rates

steroid use rates

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

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